Determination of β-blocking receptor drugs in silica gel TLC systems with the mobile phase containing surfactant

نویسندگان

چکیده

Abstract Eight drugs blocking beta-adrenergic receptors activity (acebutolol, alprenolol, atenolol, oxprenolol, labetalol, metoprolol, propranolol and sotalol) were investigated through the use of thin-layer technique with its mobile phase containing surfactant. Assessment effect surfactant presence 1-propanol concentration in on retention separation solutes was then carried out wherein zone shape properties (asymmetry tailing coefficient) investigated. The method applied for quantitative analysis chosen solutes, LOD LOQ values determined. These as follows: acebutolol – 1.11 3.36 μg/spot, metoprolol 1.45 4.4 μg/spot. system is environmentally friendly due to using silica gel plates only 5% propanol water.

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ژورنال

عنوان ژورنال: Current Issues in Pharmacy and Medical Sciences

سال: 2022

ISSN: ['2084-980X', '2300-6676']

DOI: https://doi.org/10.2478/cipms-2022-0037